Journal article

SENSITIVITY INVITRO OF GIARDIA-INTESTINALIS TO DYADIC COMBINATIONS OF AZITHROMYCIN, DOXYCYCLINE, MEFLOQUINE, TINIDAZOLE AND FURAZOLIDONE

AA CROUCH, WK SEOW, LM WHITMAN, YH THONG

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | ROYAL SOC TROPICAL MEDICINE | Published : 1990

Abstract

The new macrolide antibiotic, azithromycin, produced significant growth inhibition of Giardia intestinalis at 100 micrograms/ml, but adherence inhibition was significant at concentrations as low as 1 microgram/ml for the two strains used in these experiments. The dyadic combinations of azithromycin-furazolidone, doxycycline-mefloquine, doxycycline-tinidazole and mefloquine-tinidazole were synergistic for inhibition of adherence. These results suggest that these dyadic combinations may be worthy of consideration for chemotherapy of recalcitrant giardiasis.

University of Melbourne Researchers