Journal article

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle.

Janne R Hingst, Lea Bruhn, Mads B Hansen, Marie F Rosschou, Jesper B Birk, Joachim Fentz, Marc Foretz, Benoit Viollet, Kei Sakamoto, Nils J Færgeman, Jesper F Havelund, Benjamin L Parker, David E James, Bente Kiens, Erik A Richter, Jørgen Jensen, Jørgen FP Wojtaszewski

Mol Metab | Published : 2018

Abstract

OBJECTIVE: A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in prior exercised muscle. Our objective was to illuminate molecular mechanisms underlying this phenomenon in skeletal muscle of man. METHODS: We studied the temporal regulation of glycogen supercompensation in human skeletal muscle during a 5 day recovery period following a single bout of exercise. Nine healthy men depleted (day 1), normalized (day 2) and supercompensated (day 5) muscle glycogen in one leg while the contralateral leg served as a resting control. Euglycemic hyperinsulinemic clamps in combination with leg balance technique allowed for investigating insulin-stimulated l..

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University of Melbourne Researchers