Journal article
Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle
JR Hingst, L Bruhn, MB Hansen, MF Rosschou, JB Birk, J Fentz, M Foretz, B Viollet, K Sakamoto, NJ Færgeman, JF Havelund, BL Parker, DE James, B Kiens, EA Richter, J Jensen, JFP Wojtaszewski
Molecular Metabolism | ELSEVIER | Published : 2018
Abstract
Objective: A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in prior exercised muscle. Our objective was to illuminate molecular mechanisms underlying this phenomenon in skeletal muscle of man. Methods: We studied the temporal regulation of glycogen supercompensation in human skeletal muscle during a 5 day recovery period following a single bout of exercise. Nine healthy men depleted (day 1), normalized (day 2) and supercompensated (day 5) muscle glycogen in one leg while the contralateral leg served as a resting control. Euglycemic hyperinsulinemic clamps in combination with leg balance technique allowed for investigating insulin-stimulated l..
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Awarded by Københavns Universitet
Funding Acknowledgements
This study was supported by grants from the Danish Council for Independent Research Medical Sciences (FSS 6110-00498B to JFPW), The Novo Nordisk Foundation (NNF 16OC0023046, NNF 170OC00272224 to JFPW, NNF -12009-2015 to JFPW), The Lundbeck Foundation (R221-2016-0027/R180-2014-3887 to JFPW), Ministry of Culture Denmark (FPK 2016-0027 to JFPW), The research program "Physical activity and nutrition for improvement of health" funded by the University of Copenhagen Excellence Program for Interdisciplinary Research (to BK, JFPW and EAR). Prof. Jorgen Jensen was supported by a visiting professorship provided by the Danish Diabetes Academy supported by the Novo Nordisk Foundation. This work was supported by an NHMRC Project grant (APP1122376). B.L.P. and D.E.J. are funded by NHMRC fellowships. The contents of the published material are solely the responsibility of the individual authors and do not reflect the view of any of the funding bodies.