Journal article
A niche-dependent myeloid transcriptome signature defines dormant myeloma cells
WH Khoo, G Ledergor, A Weiner, DL Roden, RL Terry, MM McDonald, RC Chai, K De Veirman, KL Owen, KS Opperman, K Vandyke, JR Clark, A Seckinger, N Kovacic, A Nguyen, ST Mohanty, JA Pettitt, Y Xiao, AP Corr, C Seeliger Show all
Blood | AMER SOC HEMATOLOGY | Published : 2019
Abstract
The era of targeted therapies has seen significant improvements in depth of response, progression-free survival, and overall survival for patients with multiple myeloma. Despite these improvements in clinical outcome, patients inevitably relapse and require further treatment. Drug-resistant dormant myeloma cells that reside in specific niches within the skeleton are considered a basis of disease relapse but remain elusive and difficult to study. Here, we developed a method to sequence the transcriptome of individual dormant myeloma cells from the bones of tumor-bearing mice. Our analyses show that dormant myeloma cells express a distinct transcriptome signature enriched for immune genes and,..
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Awarded by Ernest Heine Family Foundation
Funding Acknowledgements
This work was supported by Janice Gibson and the Ernest Heine Family Foundation, the National Health and Medical Research Council (NHMRC; 1139237, 1104031, and 1140996), a Kay Stubbs Cancer Research Grant, a Cancer Council New South Wales Grant, Peter and Val Duncan, the Ann Helene Toakley Charitable Endowment, the Deutsche Forschungsgemeinschaft (SFB/TRR79, TP B1, B12, M9), and the German Federal Ministry of Education (CLIOMMICS; 01ZX1609A) and (CAMPSIMM; 01ES1103). K.D.V. is a postdoctoral fellow of Fonds Wetenschappelijk Onderzoek-Vlaanderen; T.G.P. is an NHMRC Senior Research Fellow (1155678). Biospecimens were provided by the South Australian Cancer Research Biobank, which is supported by the Cancer Council SA Beat Cancer Project, Medvet Laboratories Pty Ltd, and the Government of South Australia.