A unique aspartyl protease gene expansion in Talaromyces marneffei plays a role in growth inside host phagocytes
Michael Payne, Harshini Weerasinghe, Irma Tedja, Alex Andrianopoulos
VIRULENCE | TAYLOR & FRANCIS INC | Published : 2019
Aspartyl proteases are a widely represented class of proteolytic enzymes found in eukaryotes and retroviruses. They have been associated with pathogenicity in a range of disease-causing microorganisms. The dimorphic human-pathogenic fungus Talaromyces marneffei has a large expansion of these proteases identified through genomic analyses. Here we characterize the expansion of these genes (pop - paralogue of pep) and their role in T. marneffei using computational and molecular approaches. Many of the genes in this monophyletic family show copy number variation and positive selection despite the preservation of functional regions and possible redundancy. We show that the expression profile of t..View full abstract
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Awarded by National Health and Medical Research Council
This work was supported by the National Health and Medical Research Council .