Journal article

Cirrus: An Automated Mammography-Based Measure of Breast Cancer Risk Based on Textural Features

Daniel F Schmidt, Enes Makalic, Benjamin Goudey, Gillian S Dite, Jennifer Stone, Tuong L Nguyen, James G Dowty, Laura Baglietto, Melissa C Southey, Gertraud Maskarinec, Graham G Giles, John L Hopper

JNCI Cancer Spectrum | OXFORD UNIV PRESS | Published : 2018

Abstract

Background: We applied machine learning to find a novel breast cancer predictor based on information in a mammogram. Methods: Using image-processing techniques, we automatically processed 46 158 analog mammograms for 1345 cases and 4235 controls from a cohort and case-control study of Australian women, and a cohort study of Japanese American women, extracting 20 textural features not based on pixel brightness threshold. We used Bayesian lasso regression to create individual- and mammogram-specific measures of breast cancer risk, Cirrus. We trained and tested measures across studies. We fitted Cirrus with conventional mammographic density measures using logistic regression, and computed odds ..

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