The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance

Matthew J Watt; Paula M Miotto; William De Nardo; Magdalene K Montgomery

Journal article

The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance

Matthew J Watt, Paula M Miotto, William De Nardo, Magdalene K Montgomery

ENDOCRINE REVIEWS | ENDOCRINE SOC | Published : 2019

DOI: 10.1210/er.2019-00034

Abstract

The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. Through the use of advanced mass spectrometry "omics" approaches and detailed experimentation in cells, mice, and humans, we now understand that the liver secretes a wide array of proteins, metabolites, and noncoding RNAs (miRNAs) and that many of these secreted factors exert powerful effects on metabolic processes both in the ..

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University of Melbourne Researchers

Matthew Watt Author Anatomy and Physiology

Paula Miotto Author Anatomy and Physiology

Magdalene Montgomery Author Anatomy and Physiology

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Grants

Awarded by National Health and Medical Research Council of Australia Senior Research Fellowship

Awarded by National Health and Medical Research Council of Australia Career Development Fellowship

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

M.J.W. is supported by National Health and Medical Research Council of Australia Senior Research Fellowship APP1077703. P.M.M. is supported by a Natural Sciences and Engineering Research Council of Canada Postdoctoral Fellowship. W.D.N. is supported by aMelbourne Research Scholarship (University of Melbourne). M.K.M. is supported by National Health and Medical Research Council of Australia Career Development Fellowship APP1143224. The authors acknowledge the support of National Health and Medical Research Council of Australia Grants APP1162511 (to M.J.W.) and APP1156508 (to M.J.W.).