Journal article

Small molecules, big effects: the role of microRNAs in regulation of cardiomyocyte death

J Skommer, I Rana, FZ Marques, W Zhu, Z Du, FJ Charchar

CELL DEATH & DISEASE | NATURE PUBLISHING GROUP | Published : 2014

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs involved in posttranscriptional regulation of gene expression, and exerting regulatory roles in plethora of biological processes. In recent years, miRNAs have received increased attention for their crucial role in health and disease, including in cardiovascular disease. This review summarizes the role of miRNAs in regulation of cardiac cell death/cell survival pathways, including apoptosis, autophagy and necrosis. It is envisaged that these miRNAs may explain the mechanisms behind the pathogenesis of many cardiac diseases, and, most importantly, may provide new avenues for therapeutic intervention that will limit cardiomyocyte cell deat..

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University of Melbourne Researchers