Journal article
Exercise: Putting action into our epigenome
J Denham, FZ Marques, BJ O'Brien, FJ Charchar
Sports Medicine | ADIS INT LTD | Published : 2014
Abstract
Most human phenotypes are influenced by a combination of genomic and environmental factors. Engaging in regular physical exercise prevents many chronic diseases, decreases mortality risk and increases longevity. However, the mechanisms involved are poorly understood. The modulating effect of physical (aerobic and resistance) exercise on gene expression has been known for some time now and has provided us with an understanding of the biological responses to physical exercise. Emerging research data suggest that epigenetic modifications are extremely important for both development and disease in humans. In the current review, we summarise findings on the effect of exercise on epigenetic modifi..
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Funding Acknowledgements
The authors would like to thank the Victorian Government's Infrastructure Support Program and the University of Ballarat 'Self-sustaining Regions Research and Innovation Initiative', an Australian Government Collaborative Research Network (CRN), for their support. Joshua Denham is supported by an Australian Postgraduate Award. Dr Francine Marques is supported by a National Health and Medical Research Council (NHMRC) and National Heart Foundation (NHF) fellowship. Professor Charchar is supported by the Lew Carty Charitable fund and NHMRC.