Journal article

Complex events in the evolution of the human pseudoautosomal region 2 (PAR2)

FJ Charchar, M Svartman, N El-Mogharbel, M Ventura, P Kirby, MR Matarazzo, A Ciccodicola, M Rocchi, M D'Esposito, JAM Graves

GENOME RESEARCH | COLD SPRING HARBOR LAB PRESS | Published : 2003

Abstract

The 320-kb human pseudoautosomal region 2 (PAR2) at the tips of the long arms of the X and Y chromosomes is thought to have been duplicated onto the Y chromosome recently in primate evolution. The four genes within PAR2 have been proposed to constitute two zones with different base ratios and transcription, one of which was added recently to the X chromosome. To test this hypothesis, we cloned and mapped PAR2 genes in other species, the lemur, the cat, and a marsupial, the tammar wallaby. None of the human PAR2 genes colocalized with human PAR1 genes in the marsupial genome, confirming that the human PAR1 and PAR2 evolved independently. Of the four PAR2 genes, only SYBL1 was located on the X..

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University of Melbourne Researchers