FIBROBLAST GROWTH FACTOR BINDING PROTEIN 1 GENE (FGFBP1) AND HYPERTENSION FROM PATHWAY ANALYSIS TO RENAL GLOMERULUS

Abstract

Essential hypertension is a complex, multifactorial disease with a strong genetic component. Fibroblast growth factor 1 gene (FGF1) is one of the most relevant candidates having been associated not only with familial susceptibility to hypertension but also with up-regulation within the glomerulus of the human hypertensive kidney/Circulation 2007;116:1915–24/. We have hypothesised that systematic analysis of genes interacting with FGF1 may uncover novel variants underlying essential hypertension. Seventy-nine common (minor allele frequency≥0.1) tagging (r2≥0.8) and functional single nucleotide polymorphisms (SNPs) spanning eight critical components of the FGF (fibroblast growth factor) pathwa..