EFFECT OF RENAL DENERVATION ON BLOOD PRESSURE AND MICRORNA 181A IN HYPERTENSIVE SCHLAGER MICE

Abstract

Objective: Hypertensive Schlager mice (BPH) are hypertensive due to an exaggerated contribution of the sympathetic nervous system (SNS) and renin angiotensin system (RAS). The latter was associated with reduced expression of the renin regulatory micro RNA-181a. We therefore determined the effect of bilateral renal denervation (Rx) on blood pressure in BPH compared to normotensive BPN. Design and method: Blood pressure was measured by in 16 week old conscious mice by radiotelemetry and Rx was performed by surgery and 10% phenol application. Results: After 3 weeks recovery, mean 24 hour blood pressure in BPH was 110 ± 1 mmHg in BPN and 128 ± 2 mmHg in BPH. Blood pressure was 8 ± 2 mmHg lower t..