Book Chapter

Principles and Application of Molecular Imaging for Personalized Medicine and Guiding Interventions in Neuroendocrine Tumors

MS Hofman

Contemporary Endocrinology | Published : 2017


The use of molecular imaging has been transformational in guiding interventions in patients with neuroendocrine tumors. The use of Ga-68 somatostatin receptor (SSTR) in PET/CT is more accurate than In-111 planar or SPECT/CT imaging with a consequent high management impact for patients. SSTR PET/CT not only provides high sensitivity and specificity but enables noninvasive evaluation of SSTR cell expression, thereby enabling selection of patients that are suitable for somatostatin analogue or peptide receptor radionuclide therapy. Fluorodeoxyglucose (FDG) is complementary with high uptake generally conferring a poor prognosis and signifying poorly differentiated disease. An increasing number o..

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