Vaccination with FAdV-8a induces protection against inclusion body hepatitis caused by homologous and heterologous strains
Penelope A Steer-Cope, Jeanine R Sandy, Denise O'Rourke, Peter C Scott, Glenn F Browning, Amir H Noormohammadi
AVIAN PATHOLOGY | TAYLOR & FRANCIS LTD | Published : 2019
Fowl aviadenoviruses (FAdV) are important avian pathogens, responsible for several poultry diseases prevalent worldwide, including inclusion body hepatitis (IBH). FAdV intraspecies cross-protection has been clearly demonstrated, but there is little evidence that any interspecies cross-protection exists. The present study aimed to assess the inter- and intraspecies protection between three FAdV field isolates (FAdV-8a, FAdV-8b, FAdV-11) identified in association with severe IBH outbreaks. Inocula prepared using inactivated plaque-purified virus with adjuvant Montanide™ ISA 71VG, were injected intramuscularly into 3-week-old SPF chickens. At 6-weeks of age, the birds were challenged with 106 T..View full abstract
This research was partly conducted within the Poultry Cooperative Research Centre, established and supported under the Australian Government's Cooperative Research Centres Programme. The primary author of this investigation was supported by scholarships from The University of Melbourne and the Poultry Cooperative Research Centre.