Journal article

Vaccination with FAdV-8a induces protection against inclusion body hepatitis caused by homologous and heterologous strains

Penelope A Steer-Cope, Jeanine R Sandy, Denise O'Rourke, Peter C Scott, Glenn F Browning, Amir H Noormohammadi

AVIAN PATHOLOGY | TAYLOR & FRANCIS LTD | Published : 2019

Abstract

Fowl aviadenoviruses (FAdV) are important avian pathogens, responsible for several poultry diseases prevalent worldwide, including inclusion body hepatitis (IBH). FAdV intraspecies cross-protection has been clearly demonstrated, but there is little evidence that any interspecies cross-protection exists. The present study aimed to assess the inter- and intraspecies protection between three FAdV field isolates (FAdV-8a, FAdV-8b, FAdV-11) identified in association with severe IBH outbreaks. Inocula prepared using inactivated plaque-purified virus with adjuvant Montanide™ ISA 71VG, were injected intramuscularly into 3-week-old SPF chickens. At 6-weeks of age, the birds were challenged with 106 T..

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