Chronic hepatitis C treatment outcomes in low- and middle-income countries: a systematic review and meta-analysis.
Nathan Ford, Catherine Kirby, Kasha Singh, Edward J Mills, Graham Cooke, Adeeba Kamarulzaman, Philipp duCros
Bull World Health Organ | Published : 2012
OBJECTIVE: To assess the effectiveness of treatment for hepatitis C virus (HCV) infection in low- and middle-income countries and identify factors associated with successful outcomes. METHODS: We performed a systematic review and meta-analysis of studies of HCV treatment programmes in low- and middle-income countries. The primary outcome was a sustained virological response (SVR). Factors associated with treatment outcomes were identified by random-effects meta-regression analysis. FINDINGS: The analysis involved data on 12 213 patients included in 93 studies from 17 countries. The overall SVR rate was 52% (95% confidence interval, CI: 48-56). For studies in which patients were predominantly..View full abstract