Journal article
Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood
DJ Cuthbertson, E Brown, J Koskinen, CG Magnussen, N Hutri-Kähönen, M Sabin, P Tossavainen, E Jokinen, T Laitinen, J Viikari, OT Raitakari, M Juonala
Liver International | WILEY | Published : 2019
DOI: 10.1111/liv.13993
Abstract
Background & Aims: We aimed to determine how childhood body mass index and metabolic health, along with the change in body mass index between childhood and adulthood, determine the risk of adult non-alcoholic fatty liver disease. Methods: Data from 2020 participants aged 3-18 years at baseline, followed up 31 years later, were examined to assess the utility of four childhood metabolic phenotypes (Metabolic Groups I: normal body mass index, no metabolic disturbances; II: normal body mass index, one or more metabolic disturbances; III: overweight/obese, no metabolic disturbances; IV: overweight/obese, one or more metabolic disturbances) and four life-course adiposity phenotypes (Adiposity Grou..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The Young Finns Study has been supported by Academy of Finland grants 126925, 121584, 124282, 129378 (Salve), 117797 (Gendi) and 41071 (Skidi); the Social Insurance Institution of Finland; Kuopio, Tampere and Turku University Hospital Medical Funds (grants 9M048 and 9N035); the Juho Vainio Foundation; the Paavo Nurmi Foundation; the Finnish Foundation for Cardiovascular Research; the Finnish Cultural Foundation; the Tampere Tuberculosis Foundation; and the Emil Aaltonen Foundation. This work was also funded by the National Health and Medical Research Council (grant APP1098369). C.G.M is supported by a National Heart Foundation of Australia Future Leader Fellowship (100849). J.K. was supported by Turku University Foundation, Emil Aaltonen Foundation and Urmas Pekkala Foundation.