Journal article

Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems

Rishabh Sharma, Sandy R Shultz, Marcus J Robinson, Antonio Belli, Margaret L Hibbs, Terence J O'Brien, Bridgette D Semple

BRAIN BEHAVIOR AND IMMUNITY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

Traumatic brain injury (TBI) is a serious global health issue, being the leading cause of death and disability for individuals under the age of 45, and one of the largest causes of global neurological disability. In addition to the brain injury itself, it is increasingly appreciated that a TBI may also alter the systemic immune response in a way that renders TBI patients more vulnerable to infections in the acute post-injury period. Such infections pose an additional challenge to the patient, increasing rates of mortality and morbidity, and worsening neurological outcomes. Hospitalization, surgical interventions, and a state of immunosuppression induced by injury to the central nervous syste..

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