Journal article

Aged rats have an altered immune response and worse outcomes after traumatic brain injury

Mujun Sun, Rhys D Brady, Pablo M Casillas-Espinosa, David K Wright, Bridgette D Semple, Hyun Ah Kim, Richelle Mychasiuk, Christopher G Sobey, Terence J O'Brien, Antony Vinh, Stuart J McDonald, Sandy R Shultz

BRAIN BEHAVIOR AND IMMUNITY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

Initial studies suggest that increased age is associated with worse outcomes after traumatic brain injury (TBI), though the pathophysiological mechanisms responsible for this remain unclear. Immunosenescence (i.e., dysregulation of the immune system due to aging) may play a significant role in influencing TBI outcomes. This study therefore examined neurological outcomes and immune response in young-adult (i.e., 10 weeks old) compared to middle-aged (i.e., 1 year old) rats following a TBI (i.e., fluid percussion) or sham-injury. Rats were euthanized at either 24 h or one-week post-injury to analyze immune cell populations in the brain and periphery via flow cytometry, as well as telomere leng..

View full abstract