Journal article

Are skin senescence and immunosenescence linked within individuals?

Mariette EC Waaijer, David Goldeck, David A Gunn, Diana van Heemst, Rudi GJ Westendorp, Graham Pawelec, Andrea B Maier

Aging Cell | WILEY | Published : 2019

Abstract

With advancing age, many organs exhibit functional deterioration. The age-associated accumulation of senescent cells is believed to represent one factor contributing to this phenomenon. While senescent cells are found in several different organ systems, it is not known whether they arise independently in each organ system or whether their prevalence within an individual reflects that individual's intrinsic aging process. To address this question, we studied senescence in two different organ systems in humans, namely skin and T cells in 80 middle-aged and older individuals from the Leiden Longevity Study. Epidermal p16INK4a positivity was associated with neither CD4+ nor CD8+ T-cell immunosen..

View full abstract

Grants

Awarded by European Union


Awarded by Innovation Oriented Research Program on Genomics


Awarded by Centre for Medical Systems Biology, The Netherlands Genomics Initiative/Netherlands Organization for Scientific Research


Awarded by Novo Nordisk Fonden


Funding Acknowledgements

European Union-funded Network of Excellence LifeSpan, Grant/Award Number: FP6 036894, DFG-PA 361/14-1, DFG-SFB685-B4 and DFG-PA 361/11-1; Innovation Oriented Research Program on Genomics, Grant/Award Number: IGE01014 and IGE5007; Centre for Medical Systems Biology, The Netherlands Genomics Initiative/Netherlands Organization for Scientific Research, Grant/Award Number: 05040202 and 050-060-810; Deutsche Forschungsgemeinschaft; Unilever PLC; IDEAL; RGJW is supported by grants Novo Nordisk Fonden 17OC0027812