Journal article

Nasal or throat sampling is adequate for the detection of the human respiratory syncytial virus in children with acute respiratory infections

Hoan Nguyen Van, Fiona M Russe, David AB Dance, Keoudomphone Vilivong, Souphatsone Phommachan, Chanthaphone Syladeth, Jana Lai, Ruth Lim, Melinda Morpeth, Mayfong Mayxay, Paul N Newton, Xavier DeLamballerie, Audrey Dubot-Peres



Human respiratory syncytial virus (HRSV) is one of the most important causes of acute respiratory infections (ARI) in young children. HRSV diagnosis is based on the detection of the virus in respiratory specimens. Nasopharyngeal swabbing is considered the preferred method of sampling, although there is limited evidence of the superiority of nasopharyngeal swabs (NPS) over the less invasive nasal (NS) and throat (TS) swabs for virus detection by real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR). In the current study, we compared the three swabbing methods for the detection of HRSV by RT-qPCR in children hospitalized with ARI at Mahosot Hospital, Vientiane, Laos...

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Awarded by European Union's Horizon 2020 research and innovation programme EVAg

Awarded by Bill & Melinda Gates Foundation

Awarded by Wellcome Trust of Great Britain

Funding Acknowledgements

Murdoch Children's Research Institute; European Union's Horizon 2020 research and innovation programme EVAg, Grant/Award Number: 653316; Aix-Marseille University; Bill & Melinda Gates Foundation, Grant/Award Number: OPP1115490; Wellcome Trust of Great Britain, Grant/Award Number: 089275/H/09/Z0; Institute of Research for Development