Targeted Therapy Against the Cell of Origin in Cutaneous Squamous Cell Carcinoma
Stephen J Goldie, Ginevra Chincarini, Charbel Darido
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2019
Squamous cell carcinomas (SCC), including cutaneous SCCs, are by far the most frequent cancers in humans, accounting for 80% of all newly diagnosed malignancies worldwide. The old dogma that SCC develops exclusively from stem cells (SC) has now changed to include progenitors, transit-amplifying and differentiated short-lived cells. Accumulation of specific oncogenic mutations is required to induce SCC from each cell population. Whilst as fewer as one genetic hit is sufficient to induce SCC from a SC, multiple events are additionally required in more differentiated cells. Interestingly, the level of differentiation correlates with the number of transforming events required to induce a stem-li..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by Victorian Cancer Agency
This research was supported by grants from the Australian National Health and Medical Research Council (NHMRC, APP1049870, APP1106697) and by Fellowships from the Victorian Cancer Agency (Clare Oliver Memorial, COF11_04 and Mid-Career, MCRF16017) to CD.