Journal article

Targeted Therapy Against the Cell of Origin in Cutaneous Squamous Cell Carcinoma

Stephen J Goldie, Ginevra Chincarini, Charbel Darido

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2019

Abstract

Squamous cell carcinomas (SCC), including cutaneous SCCs, are by far the most frequent cancers in humans, accounting for 80% of all newly diagnosed malignancies worldwide. The old dogma that SCC develops exclusively from stem cells (SC) has now changed to include progenitors, transit-amplifying and differentiated short-lived cells. Accumulation of specific oncogenic mutations is required to induce SCC from each cell population. Whilst as fewer as one genetic hit is sufficient to induce SCC from a SC, multiple events are additionally required in more differentiated cells. Interestingly, the level of differentiation correlates with the number of transforming events required to induce a stem-li..

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