Journal article

The Impact of Childhood Adversity on Cognitive Development in Schizophrenia

Ruth Wells, Isabella Jacomb, Vaidy Swaminathan, Suresh Sundram, Danielle Weinberg, Jason Bruggemann, Vanessa Cropley, Rhoshel K Lenroot, Avril M Pereira, Andrew Zalesky, Chad Bousman, Christos Pantelis, Cynthia Shannon Weickert, Thomas W Weickert

Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2020

Abstract

Childhood adversity, such as physical, sexual, and verbal abuse, as well as neglect and family conflict, is a risk factor for schizophrenia. Such adversity can lead to disruptions of cognitive function during development, undermining intellectual capabilities and academic achievement. Schizophrenia is a neurodevelopmental disorder that is associated with cognitive impairments that may become evident during childhood. The Australian Schizophrenia Research Bank database comprises a large community cohort (N = 1169) in which we previously identified 3 distinct cognitive groups among people with schizophrenia: (1) Compromised, current, and estimated premorbid cognitive impairment; (2) Deteriorat..

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Grants

Awarded by Australian NHMRC Principal Research Fellowship


Awarded by Australian NHMRC Senior Principal Research Fellowship


Awarded by Australian NHMRC Career Development Fellowship


Funding Acknowledgements

This work was supported by the University of New South Wales School of Psychiatry, Neuroscience Research Australia, the Schizophrenia Research Laboratory utilizing infrastructure funding from NSW Ministry of Health Office of Health and Medical Research and the Macquarie Group Foundation, and the Australian Schizophrenia Research Bank which was supported by the Australian National Health and Medical Research Council (NHMRC), the Pratt Foundation, Ramsay Health Care, and the Viertel Charitable Foundation. An Australian NHMRC Principal Research Fellowship (#1021970) supported C. S. Weickert. An Australian NHMRC Senior Principal Research Fellowship (ID: 1117079) supported Pantelis. An Australian NHMRC Career Development Fellowship (#1127700) supported Bousman.