Journal article

Nocturnal symptoms perceived as asthma are associated with obstructive sleep apnoea risk, but not bronchial hyper-reactivity

Chamara V Senaratna, E Haydn Walters, Garun Hamilton, Adrian J Lowe, Caroline Lodge, John Burgess, Bircan Erbas, Graham G Giles, Paul Thomas, Michael J Abramson, Bruce Thompson, Jennifer L Perret, Shyamali C Dharmage

Respirology | WILEY | Published : 2019

Abstract

BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) and asthma are associated, and nocturnal breathing difficulty that is usually identified as asthma-like symptoms can be present in both conditions. We investigated how nocturnal asthma-like symptoms (NAS) and bronchial hyper-reactivity (BHR) contribute to the association between OSA risk and current asthma, which is currently unknown but a clinically important question. METHODS: We used data from 794 middle-aged participants in a population-based cohort who provided information on OSA risk (defined by a STOP-Bang questionnaire score of at least 3), current asthma and NAS, and underwent methacholine bronchial challenge testing. Using re..

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