Journal article

Genetic and Early-Life Environmental Influences on Dental Caries Risk: A Twin Study

Mihiri J Silva, Nicky M Kilpatrick, Jeffrey M Craig, David J Manton, Pamela Leong, David P Burgner, Katrina J Scurrah

PEDIATRICS | AMER ACAD PEDIATRICS | Published : 2019

Abstract

OBJECTIVES: To explore the relative contributions of genetic and environmental influences on dental caries risk and to investigate fetal and developmental risk factors for dental caries. METHODS: We recruited children from 250 twin pregnancies midgestation and collected demographic, health, and phenotypic data at recruitment, 24 and 36 weeks' gestational age, birth and 18 months, and 6 years of age. 25-hydroxyvitamin D was quantified in mothers at 28 weeks' gestation and in infants at birth. Dental caries and enamel defects were measured at six years of age. We compared concordance for the presence of any caries and advanced caries in monozygotic and dizygotic twin pairs. To investigate envi..

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Grants

Awarded by National Institute of Dental and Craniofacial Research of the National Institutes of Health


Awarded by Australian National Health and Medical Research Council


Awarded by Bonnie Babes Foundation


Awarded by Financial Markets Foundation for Children


Awarded by National Health and Medical Research Council


Funding Acknowledgements

Supported by the National Institute of Dental and Craniofacial Research of the National Institutes of Health (award R01DE019665). The Peri/postnatal Epigenetic Twins Study was supported by grants from the Australian National Health and Medical Research Council (grants 437015 and 607358), the Bonnie Babes Foundation (grant BBF20704), the Financial Markets Foundation for Children (grant 032-2007), the Victorian government's Operational Infrastructure Support Program, the Australian and New Zealand Society for Paediatric Dentistry (Victorian branch), and the University of Melbourne Paediatric Dentistry Fund. Dr Silva is supported by a National Health and Medical Research Council Postgraduate Health Research Scholarship. Dr Scurrah is supported by a Centre of Research Excellence grant in twin research and a National Health and Medical Research Council project grant (1084197). Funded by the National Institutes of Health (NIH).