Distributions and relationships of chemically defined enteroendocrine cells in the rat gastric mucosa
Billie Hunne, Martin J Stebbing, Rachel M McQuade, John B Furness
CELL AND TISSUE RESEARCH | SPRINGER | Published : 2019
This paper provides quantitative data on the distributions of enteroendocrine cells (EEC), defined by the hormones they contain, patterns of colocalisation between hormones and EEC relations to nerve fibres in the rat gastric mucosa. The rat stomach has three mucosal types: non-glandular stratified squamous epithelium of the fundus and esophageal groove, a region of oxyntic glands in the corpus, and pyloric glands of the antrum and pylorus. Ghrelin and histamine were both contained in closed cells, not contacting the lumen, and were most numerous in the corpus. Gastrin cells were confined to the antrum, and 5-hydroxytryptamine (5-HT) and somatostatin cells were more frequent in the antrum th..View full abstract
Awarded by NIH (SPARC) grant
Awarded by OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
This work was supported by NIH (SPARC) grant ID #OT2OD023847 (PI Terry Powley) to JBF.