Journal article

Sex and puberty-related differences in metabolomic profiles associated with adiposity measures in youth with obesity

Christoph Saner, Brooke E Harcourt, Ahwan Pandey, Susan Ellul, Zoe McCallum, Kung-Ting Kao, Celia Twindyakirana, Anke Pons, Erin J Alexander, Richard Saffery, David P Burgner, Markus Juonala, Matthew A Sabin

METABOLOMICS | SPRINGER | Published : 2019

Abstract

BACKGROUND: Specific patterns of metabolomic profiles relating to cardiometabolic disease are associated with increased weight in adults. In youth with obesity, metabolomic data are sparse and associations with adiposity measures unknown. OBJECTIVES: Primary, to determine associations between adiposity measures and metabolomic profiles with increased cardiometabolic risks in youth with obesity. Secondary, to stratify associations by sex and puberty. METHODS: Participants were from COBRA (Childhood Overweight BioRepository of Australia; a paediatric cohort with obesity). Adiposity measures (BMI, BMI z-score, %truncal and %whole body fat, waist circumference and waist/height ratio), puberty st..

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Grants

Awarded by NHMRC Senior Research Fellowship


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

Authors from the Murdoch Children's Research Institute are supported in part by the Victorian Government Operational Infrastructure Support Program. CS was supported for a 1 year clinical research fellowship position at the Endocrinology Department at the Royal Children's Hospital by "Batzebaer Foundation", Inselspital Bern; "Fondazione Ettore e Valeria Rossi"; "Freie akademische Gesellschaft Basel" and "NovoNordisk", all Switzerland. CS declares that he has no conflict of interest to declare. BEH is an NHMRC Peter Doherty ECF Fellow (APP: 1072086). BEH declares that he has no conflict of interest to declare. DPB is supported by NHMRC Senior Research Fellowship (1064629) and an Honorary Future Leader Fellowship of the National Heart Foundation of Australia (100369). DPB declares that he has no conflict of interest to declare. MJ was supported by Juho Vainio Foundation and federal research grants to Turku University Hospital. MJ declares that he has no conflict of interest to declare. The funding bodies did not play any role in this study or the decision to publish.