Journal article

Cognitive effects of brief and ultrabrief pulse bitemporal electroconvulsive therapy: a randomised controlled proof-of-concept trial

Donel Martin, Natalie Katalinic, Dusan Hadzi-Pavlovic, Anna Ingram, Nicholas Ingram, Brett Simpson, Jenny McGoldrick, Nathan Dowling, Colleen Loo

Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2020


BACKGROUND: Reduction of the pulse width has been reported to improve ECT outcomes with unilateral ECT (similar efficacy, fewer cognitive side effects), but has been minimally studied for bitemporal ECT. The only study comparing brief and ultrabrief pulse bitemporal ECT found reduced efficacy for bitemporal ultrabrief compared to bitemporal brief pulse stimulation. This randomised controlled trial (RCT) aimed to test if ultrabrief pulse bitemporal ECT results in fewer cognitive side effects than brief pulse bitemporal ECT, when given at doses adjusted with the aim of achieving comparable efficacy. METHODS: Thirty-six participants were randomly assigned to receive ultrabrief (at 3 times seizu..

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University of Melbourne Researchers


Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This work was funded by an Australian National Health and Medical Research Council (NHMRC) project grant (ID 568678).