Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer
Yuxuan Wang, Lu Li, Joshua D Cohen, Isaac Kinde, Janine Ptak, Maria Popoli, Joy Schaefer, Natalie Silliman, Lisa Dobbyn, Jeanne Tie, Peter Gibbs, Cristian Tomasetti, Kenneth W Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Louise Olsson
JAMA Oncology | AMER MEDICAL ASSOC | Published : 2019
Importance: For patients with resected, nonmetastatic colorectal cancer (CRC), the optimal surveillance protocol remains unclear. Objective: To evaluate whether serial circulating tumor DNA (ctDNA) levels detected disease recurrence earlier, compared with conventional postoperative surveillance, in patients with resected CRC. Design, Setting, and Participants: This study included patients (n = 58) with stage I, II, or III CRC who underwent radical surgical resection at 4 Swedish hospitals from February 2, 2007, to May 8, 2013. Eighteen patients received adjuvant chemotherapy at the discretion of their clinicians, who were blinded to the ctDNA results. Blood samples were collected at 1 month ..View full abstract
Awarded by GI SPORE
Awarded by MSTP
This study was funded by the Virginia and D.K. Ludwig Fund for Cancer Research, John Templeton Foundation, the Commonwealth Foundation, grant CA 62924 from GI SPORE, grant GM 07309 from MSTP, grant CA 06973 from Oncology Core, the Marcus Foundation, the Sol Goldman Sequencing Facility at Johns Hopkins, the Conrad R. Hilton Foundation, and the Sormland County Council.