Journal article

Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study

Bruno Agustini, Mohammadreza Mohebbi, Robyn L Woods, John J McNeil, Mark R Nelson, Raj C Shah, Anne M Murray, Michael E Ernst, Christopher M Reid, Andrew Tonkin, Jessica E Lockery, Michael Berk

CNS DRUGS | ADIS INT LTD | Published : 2019

Abstract

BACKGROUND: Statin use has been frequently associated with depressive symptoms in an older population. However, the nature of this association is uncertain in the literature. In this study, we aimed to investigate the association of statin intake and the prevalence of depressive symptoms in healthy community-dwelling older adults living in Australia and the USA. METHODS: We analysed baseline data from 19,114 participants, over 70 years of age (over 65 years of age, if from an ethnic minority). The association of self-reported statin use and prevalence of depressive symptoms, as measured by a validated depression scale [Center for Epidemiological Studies Depression Scale (CES-D 10)], was dete..

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University of Melbourne Researchers

Grants

Awarded by National Cancer Institute at the National Institutes of Health


Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship


Awarded by NHMRC Senior Research Fellowship


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

The study is supported by the National Institute on Aging and the National Cancer Institute at the National Institutes of Health (Grant No. U01AG029824), the National Health and Medical Research Council of Australia (Grant Nos. 334047, 1127060), Monash University (Australia) and the Victorian Cancer Agency (Australia). Michael Berk is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (APP1059660 and APP1156072) and Christopher M. Reid is supported by a NHMRC Senior Research Fellowship (APP1045862).