Journal article

Defining the functions of adenosine-to-inosine RNA editing through hematology

Jacki E Heraud-Farlow, Alistair M Chalk, Carl R Walkley

Current Opinion in Hematology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

PURPOSE OF REVIEW: The direct modification of RNA is now understood to be widespread, evolutionarily conserved and of consequence to cellular and organismal homeostasis. adenosine-to-inosine (A-to-I) RNA editing is one of the most common mammalian RNA modifications. Transcriptome-wide maps of the A-to-I editing exist, yet functions for the majority of editing sites remain opaque. Herein we discuss how hematology has been applied to determine physiological and malignant functions of A-to-I editing. RECENT FINDINGS: Functional studies have established that A-to-I editing and ADAR1, responsible for the majority of editing in blood cells, are essential for normal blood cell homeostasis. ADAR1 ed..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Australian Research Council


Awarded by Victorian Cancer Agency Research Fellowship


Funding Acknowledgements

Our work is supported by the National Health and Medical Research Council (NHMRC; C.R.W., APP1102006/APP1144049); Australian Research Council (C.R.W.; DP180103989) Victorian Cancer Agency Research Fellowship (C.R.W.; MCRF15015); E.H. Flack Fellowship (J.H.-F.); SVI Women in Science Award (J.H.-F.); and in part by the Victorian State Government Operational Infrastructure Support (to St Vincent's Institute).