Journal article

The tammar wallaby: a non-traditional animal model to study growth axis maturation

Jennifer A Hetz, Brandon R Menzies, Geoffrey Shaw, Marilyn B Renfree

REPRODUCTION FERTILITY AND DEVELOPMENT | CSIRO PUBLISHING | Published : 2019

Abstract

Maturation of the growth hormone (GH)/insulin-like growth factor 1 (IGF1) axis is a critical developmental event that becomes functional over the peripartum period in precocial eutherian mammals such as sheep. In mice and marsupials that give birth to altricial young, the GH/IGF1 axis matures well after birth, suggesting that functional maturation is associated with developmental stage, not parturition. Recent foster-forward studies in one marsupial, the tammar wallaby (Macropus eugenii), have corroborated this hypothesis. 'Fostering' tammar young not only markedly accelerates their development and growth rates, but also affects the timing of maturation of the growth axis compared with norma..

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Grants

Awarded by Programa de Formacion de Capital Humano Avanzado (Comision Nacional de Investigacion Cientifica y Tecnologica CONICYT)


Awarded by Vicerrectoria de Investigacion y Estudios Avanzados (Pontificia Universidad Catolica de Valparaiso PUCV)


Funding Acknowledgements

Jennifer A. Hetz thanks Programa de Formacion de Capital Humano Avanzado (Comision Nacional de Investigacion Cientifica y Tecnologica CONICYT; 74170055) and to Vicerrectoria de Investigacion y Estudios Avanzados (Pontificia Universidad Catolica de Valparaiso PUCV; 37.0-2018) for postdoctoral fellowship grant.