Journal article

A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality

Chiara Sartini, Vladimir Lomivorotov, Antonio Pisano, Hynek Riha, Martina Baiardo Redaelli, Juan Carlos Lopez-Delgado, Marina Pieri, Ludhmila Hajjar, Evgeny Fominskiy, Valery Likhvantsev, Luca Cabrini, Nikola Bradic, Daniele Avancini, Chew Yin Wang, Rosalba Lembo, Maxim Novikov, Gianluca Paternoster, Gordana Gazivoda, Gabriele Alvaro, Agostino Roasio Show all

Journal of Cardiothoracic and Vascular Anesthesia | W B SAUNDERS CO-ELSEVIER INC | Published : 2019

Abstract

OBJECTIVE: Reducing mortality is a key target in critical care and perioperative medicine. The authors aimed to identify all nonsurgical interventions (drugs, techniques, strategies) shown by randomized trials to increase mortality in these clinical settings. DESIGN: A systematic review of the literature followed by a consensus-based voting process. SETTING: A web-based international consensus conference. PARTICIPANTS: Two hundred fifty-one physicians from 46 countries. INTERVENTIONS: The authors performed a systematic literature search and identified all randomized controlled trials (RCTs) showing a significant increase in unadjusted landmark mortality among surgical or critically ill patie..

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University of Melbourne Researchers