Journal article

Early in-situ cellularization of a supramolecular vascular graft is modified by synthetic stromal cell-derived factor-1 alpha derived peptides

Dimitri EP Muylaert, Geert C van Almen, Hanna Talacua, Joost O Fledderus, Jolanda Kluin, Simone IS Hendrikse, Joost LJ van Dongen, Eline Sijbesma, Anton W Bosman, Tristan Mes, Shraddha H Thakkar, Anthal IPM Smits, Carlijn VC Bouten, Patricia YW Dankers, Marianne C Verhaar

BIOMATERIALS | ELSEVIER SCI LTD | Published : 2016

Abstract

In an in-situ approach towards tissue engineered cardiovascular replacement grafts, cell-free scaffolds are implanted that engage in endogenous tissue formation. Bioactive molecules can be incorporated into such grafts to facilitate cellular recruitment. Stromal cell derived factor 1α (SDF1α) is a powerful chemoattractant of lymphocytes, monocytes and progenitor cells and plays an important role in cellular signaling and tissue repair. Short SDF1α-peptides derived from its receptor-activating domain are capable of activating the SDF1α-specific receptor CXCR4. Here, we show that SDF1α-derived peptides can be chemically modified with a supramolecular four-fold hydrogen bonding ureido-pyrimidin..

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University of Melbourne Researchers

Grants

Awarded by BioMedical Materials institute


Awarded by Ministry of Education, Culture and Science


Awarded by European Research Council


Awarded by Netherlands Institute for Regenerative Medicine (NIRM)


Funding Acknowledgements

This research forms part of the Project P1.01 iValve of the research program of the BioMedical Materials institute, co-funded by the Dutch Ministry of Economic Affairs.The financial contribution of the Nederlandse Hartstichting is gratefully acknowledged.Part of this research is funded by the Ministry of Education, Culture and Science (Gravity program 024.001.035), the Netherlands Organisation for Scientific Research (NWO), the European Research Council (FP7/2007-2013), ERC Grant Agreement 308045 and the Netherlands Institute for Regenerative Medicine (NIRM) (Grant No. FES0908).