Oral Fluid Testing for Cocaine: Analytical Evaluation of Two Point-of-Collection Drug Screening Devices
Juliana Nichterwitz Scherer, Tais Regina Fiorentin, Tanara Rosangela Vieira Sousa, Renata Pereira Limberger, Flavio Pechansky
JOURNAL OF ANALYTICAL TOXICOLOGY | OXFORD UNIV PRESS INC | Published : 2017
The use of point-of-collection testing (POCT) devices for drugs of abuse in oral fluid (OF) is an advantageous tool that has been used for different purposes-particularly traffic enforcement. However, even with the widespread report of cocaine consumption, the reliability of POCT devices has been reported in different magnitudes. This study evaluated the reliability of two POCT devices for the detection of cocaine in OF samples of 110 cocaine users: (i) the DDS2™ (cutoff = 30 ng/mL) and (ii) the Multi-Drugs Multi-Line-Twist Screen Test Device™ (MDML) (cutoff = 20 ng/mL). Results of the screening tests were compared with a Liquid Chromatography-Mass Spectrometry (LC-MS) assay. Sensitivity, sp..View full abstract
Funding for this research was provided by Secretaria Nacional de Politicas sobre Drogas (SENAD) and Fundo de Incentivo a Pesquisa-Hospital de Clinicas de Porto Alegre (FIPE-HCPA). J.N.S. and T.R.F. received scholarship funded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES). R.P.L. and F.P. received scholarship funded by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq). The test kits used in this study were donated by the manufacturers. The funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.