Journal article

Endothelin-2 Injures the Blood-Retinal Barrier and Macroglial Muller Cells Interactions with Angiotensin II, Aldosterone, and NADPH Oxidase

Saeed F Alrashdi, Devy Deliyanti, Dean M Talia, Jennifer L Wilkinson-Berka

AMERICAN JOURNAL OF PATHOLOGY | ELSEVIER SCIENCE INC | Published : 2018

Abstract

Although increasing evidence indicates that endothelin-2 (Edn2) has distinct roles in tissue pathology, including inflammation, glial cell dysfunction, and angiogenesis, its role in the retina and the factors that regulate its actions are not fully understood. We hypothesized that Edn2 damages the blood-retinal barrier (BRB) and that this is mediated by interactions with the renin-angiotensin-aldosterone system and reactive oxygen species derived from NADPH oxidase (Nox). C57BL/6J mice received an intravitreal injection of Edn2 or control vehicle to examine the blood pressure-independent effects of Edn2. Mice administered Edn2 were randomized to receive by intraperitoneal injection treatment..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Ministry of Education of Saudi Arabia PhD scholarship


Awarded by JDRF postdoctoral fellowship


Funding Acknowledgements

Supported by the Ministry of Education of Saudi Arabia PhD scholarship 1021389984 (S.F.A.), JDRF postdoctoral fellowship 3-PDF-2017-376-A-N (D.D.), and National Health and Medical Research Council of Australia project grant 1078442 (J.L.W.-B.).