Journal article

RENIN PROCESSING STUDIED BY IMMUNOGOLD LOCALIZATION OF PRORENIN AND RENIN IN GRANULAR JUXTAGLOMERULAR CELLS IN MICE TREATED WITH ENALAPRIL

JLA BERKA, D ALCORN, GB RYAN, SL SKINNER

CELL AND TISSUE RESEARCH | SPRINGER VERLAG | Published : 1992

Abstract

Immunogold techniques were used to investigate renin processing within granular juxtaglomerular cells following short-term (6 h and 1 day) and long-term (4 weeks) enalapril treatment in female BALB/c mice. In control animals, renin protein labelling was localized to all types of granules (proto-, polymorphous, intermediate and mature) and to transport vesicles, whilst prorenin labelling was found in all these sites except mature granules, confirming that active renin is localized to mature granules only. Following short-term enalapril treatment, the exocytosis of renin protein from mature granules was increased. Long-term enalapril treatment resulted in increased numbers of transport vesicle..

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