Conference Proceedings

Adult herpes simplex encephalitis: Fifteen years' experience

Antoni Riera-Mestre, Laura Gubieras, Sergio Martinez-Yelamos, Carmen Cabellos, Pedro Fernandez-Viladrich

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | EDICIONES DOYMA S A | Published : 2009

Abstract

INTRODUCTION: Herpes simplex encephalitis (HSE) is the most frequent cause of sporadic necrotizing encephalitis in adults. The aim of this study is to describe the characteristics of HSE and the factors influencing its outcome. MATERIAL AND METHODS: Retrospective study of patients diagnosed with HSE in a tertiary care teaching hospital over a 15-year period. Diagnosis was based on a consistent clinical profile for HSE, plus either a PCR-positive CSF HSV study or consistent brain neuroimaging findings. Patients were divided into 2 groups according to the modified Rankin Scale: good outcome (Grades =3). RESULTS: Thirty-five patients were included. Mean age was 53.9 years. More than half presen..

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