COMT val158met is not associated with A beta-amyloid and APOE epsilon 4 related cognitive decline in cognitively normal older adults

Tenielle Porter; Samantha C Burnham; Lidija Milicic; Greg Savage; Paul Maruff; Hamid R Sohrabi; Madeline Peretti; Yen Ying Lim; Michael Weinborn; David Ames; Colin L Masters; Ralph N Martins; Stephanie Rainey-Smith; Christopher C Rowe; Olivier Salvado; David Groth; Giuseppe Verdile; Victor L Villemagne; Simon M Laws

Journal article

COMT val158met is not associated with A beta-amyloid and APOE epsilon 4 related cognitive decline in cognitively normal older adults

Tenielle Porter, Samantha C Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Hamid R Sohrabi, Madeline Peretti, Yen Ying Lim, Michael Weinborn, David Ames, Colin L Masters, Ralph N Martins, Stephanie Rainey-Smith, Christopher C Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L Villemagne, Simon M Laws

IBRO Reports | ELSEVIER | Published : 2019

DOI: 10.1016/j.ibror.2019.05.001

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Abstract

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer's disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant indepe..

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University of Melbourne Researchers

Yen Ying Lim Author Florey Department of Neuroscience and Mental Health

Colin Masters Author Florey Department of Neuroscience and Mental Health

Christopher Rowe Author Florey Department of Neuroscience and Mental Health

David Ames Author Psychiatry

Victor Villemagne Author Medicine - Austin Health

Grants

Awarded by Cooperative Research Centre (CRC) for Mental Health through the CRC Program, an Australian Government Initiative

Funding Acknowledgements

Funding for the AIBL study was provided in part by the study partners [Commonwealth Scientific Industrial and research Organization (CSIRO), Edith Cowan University (ECU), Mental Health Research institute (MHRI), National Ageing Research Institute (NARI), Austin Health, CogState Ltd.]. The AIBL study has also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre (CRC) for Mental Health -funded through the CRC Program (Grant ID: 20100104), an Australian Government Initiative.