Journal article

Effects of the hierarchical macro/mesoporous structure on the osteoblast-like cell response.

Ranran Zhang, Tarek A Elkhooly, Qianli Huang, Xujie Liu, Xing Yang, Hao Yan, Zhiyuan Xiong, Jing Ma, Qingling Feng, Zhijian Shen

J Biomed Mater Res A | Published : 2018

Abstract

To improve the success of medical devices, implants with strong surface bioactivity are urgently required. Coatings with a macroporous structure produced by micro-arc oxidation possess advantages, such as strong adhesion to substrate and excellent resistance to wear and corrosion. Mesoporous structures contain pores with sizes of 2-50 nm, which can endow the biomaterials with the ability to enhance osteogenesis and to be loaded with diverse drugs. Thus, in this study, we aimed to evaluate the effects of both macroporous and mesoporous structures using a hierarchical macro/mesoporous structure to modify the titanium implant surface. The behaviors of SaOS-2 human osteosarcoma cells on the macr..

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University of Melbourne Researchers