Journal article

Excitation-inhibition balance regulates the patterning of spinal and cranial inspiratory motor outputs in rats in situ

Rishi R Dhingra, Werner I Furuya, Roberto F Galan, Mathias Dutschmann

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | ELSEVIER SCIENCE BV | Published : 2019

Abstract

Spinal phrenic nerve activity (PNA) drives the diaphragm but cranial hypoglossal nerve activity (HNA) also expresses synchronous activity during inspiration. Here, we investigated the effects of local disinhibition (bilateral microinjections of bicuculline) of the nucleus tractus solitarius (NTS), the pre-Bötzinger complex and Bötzinger complex core circuit (pre-BötC/BötC) and the Kölliker-Fuse nuclei (KFn) on the synchronization of PNA and HNA in arterially-perfused brainstem preparations of rats. To quantitatively analyze the bicuculline effects on a putatively distributed inspiratory central pattern generator (i-CPG), we quantified the phase synchronization properties between PNA and HNA...

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