Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Ashok Agarwal, Neel Parekh, Manesh Kumar Panner Selvam, Ralf Henkel, Rupin Shah, Sheryl T Homa, Ranjith Ramasamy, Edmund Ko, Kelton Tremellen, Sandro Esteves, Ahmad Majzoub, Juan G Alvarez, David K Gardner, Channa N Jayasena, Jonathan W Ramsay, Chak-Lam Cho, Ramadan Saleh, Denny Sakkas, James M Hotaling, Scott D Lundy Show all
The World Journal of Men's Health | KOREAN SOC SEXUAL MEDICINE & ANDROLOGY | Published : 2019
Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a..View full abstract
Financial support for this study was provided by the American Center for Reproductive Medicine.