DISRUPTION IN HIPPOCAMPAL-PREFRONTAL WHITE MATTER PATHWAYS AND MEMORY PERFORMANCE ACROSS STAGES OF SCHIZOPHRENIA-SPECTRUM DISORDER

Abstract

Memory impairment is a consistent finding in the schizophrenia literature, and it is possible that deficits are the result of disrupted connectivity between key memory-related brain regions – namely, the hippocampus and the prefrontal cortex. However, while previous studies have identified relationships between memory performance and hippocampal and cortical grey matter volumes, few studies have investigated relationships between memory performance and measures of white matter (WM) connectivity and integrity. The current study therefore examined whether deficits in episodic and working memory in early and established psychosis were related to (1) disrupted hippocampal-prefrontal WM connectiv..