Journal article

On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat

David GS Farmer, Natasha Pracejus, Bowen Dempsey, Anita Turner, Phillip Bokiniec, Julian FR Paton, Anthony E Pickering, Jasmine Burguet, Philippe Andrey, Ann K Goodchild, Robin M McAllen, Simon McMullan



KEY POINTS: Spinally-projecting neurons of the rostral ventrolateral medulla (RVLM) determine sympathetic outflow to different territories of the body. Previous studies suggest the existence of RVLM neurons with distinct functional classes, such as neurons that target sympathetic nerves bound for functionally-similar tissue types (e.g. muscle vasculature). The existence of RVLM neurons with more general actions had not been critically tested. Using viral tracing, we show that a significant minority of RVLM neurons send axon collaterals to disparate spinal segments (T2 and T10 ). Furthermore, optogenetic activation of sympathetic premotor neurons projecting to lumbar spinal segments also prod..

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Awarded by Australian Research Council

Awarded by British Heart Foundation

Awarded by LabEx Saclay Plant Sciences-SPS

Funding Acknowledgements

This work was funded by the Australian Research Council (DP130104661, DP120100920) and the Faculty of Medicine, University of Melbourne, as well as Macquarie University postgraduate scholarships (BD & PB). JFRP is funded by the British Heart Foundation (RG/12/6/29670). AEP is a Wellcome Trust Senior Clinical fellow (gr088373). We also acknowledge the support of the Victorian Government through the Operational Infrastructure Scheme. The Institut Jean-Pierre Bourgin benefits from the support of the LabEx Saclay Plant Sciences-SPS (ANR-10-LABX-0040-SPS).