Journal article

Brain Functional Connectivity Is Modified by a Hypocaloric Mediterranean Diet and Physical Activity in Obese Women

Natalia Garcia-Casares, Maria R Bernal-Lopez, Nuria Roe-Vellve, Mario Gutierrez-Bedmar, Jose C Fernandez-Garcia, Juan A Garcia-Arnes, Jose R Ramos-Rodriguez, Francisco Alfaro, Sonia Santamaria-Fernandez, Trevor Steward, Susana Jimenez-Murcia, Isabel Garcia-Garcia, Pedro Valdivielso, Fernando Fernandez-Aranda, Francisco J Tinahones, Ricardo Gomez-Huelgas

NUTRIENTS | MDPI | Published : 2017

Abstract

Functional magnetic resonance imaging (fMRI) in the resting state has shown altered brain connectivity networks in obese individuals. However, the impact of a Mediterranean diet on cerebral connectivity in obese patients when losing weight has not been previously explored. The aim of this study was to examine the connectivity between brain structures before and six months after following a hypocaloric Mediterranean diet and physical activity program in a group of sixteen obese women aged 46.31 ± 4.07 years. Before and after the intervention program, the body mass index (BMI) (kg/m²) was 38.15 ± 4.7 vs. 34.18 ± 4.5 (p < 0.02), and body weight (kg) was 98.5 ± 13.1 vs. 88.28 ± 12.2 (p < 0.03). ..

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