Identifying Possible Outcome Domains from Existing Outcome Measures to Inform an OMERACT Core Domain Set for Safety in Rheumatology Trials

Louise Klokker; Dorthe B Berthelsen; Thasia Woodworth; Kathleen M Andersen; Daniel E Furst; Dan Devoe; Paula R Williamson; Maria E Suarez-Almazor; Vibeke Strand; Amye L Leong; Niti Goel; Maarten Boers; Peter M Brooks; Lyn March; Victor S Sloan; Peter Tugwell; Lee S Simon; Robin Christensen

Journal article

Identifying Possible Outcome Domains from Existing Outcome Measures to Inform an OMERACT Core Domain Set for Safety in Rheumatology Trials

Louise Klokker, Dorthe B Berthelsen, Thasia Woodworth, Kathleen M Andersen, Daniel E Furst, Dan Devoe, Paula R Williamson, Maria E Suarez-Almazor, Vibeke Strand, Amye L Leong, Niti Goel, Maarten Boers, Peter M Brooks, Lyn March, Victor S Sloan, Peter Tugwell, Lee S Simon, Robin Christensen

JOURNAL OF RHEUMATOLOGY | J RHEUMATOL PUBL CO | Published : 2019

DOI: 10.3899/jrheum.190196

Abstract

OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Safety Working Group objective was to identify harm domains from existing outcome measurements in rheumatology. METHODS: Systematically searching the MEDLINE database on January 24, 2017, we identified full-text articles that could be used for harm outcomes in rheumatology. Domains/items from the identified instruments were described and the content synthesized to provide a preliminary framework for harm outcomes. RESULTS: From 435 possible references, 24 were read in full text and 9 were included: 7 measurement instruments were identified. Investigation of domains/items revealed considerable heterogeneity in the grouping and approach..

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