EMERGENCE OF MULTIDRUG-RESISTANCE IN CAMPYLOBACTER-JEJUNI ISOLATES FROM 3 PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS

Abstract

Single-drug resistance to tetracycline, doxycycline, erythromycin, or fluoroquinolones in Campylobacter isolates recovered from humans has been documented worldwide. Multidrug resistance to these antibiotics is rare in Campylobacter jejuni. We report the sequential development of multidrug resistance in C. jejuni isolates from three patients who were infected with human immunodeficiency virus. Multiple isolates recovered from stool specimens from these patients were ribotyped, and antibiotic susceptibility profiles were determined. The results indicated that each patient was infected with a single strain of C. jejuni that had progressively acquired resistance to the antibiotics used during t..