Journal article

Novel Receptor Specificity of Avian Gammacoronaviruses That Cause Enteritis

IN Ambepitiya Wickramasinghe, RP de Vries, EAWS Weerts, SJ van Beurden, W Peng, R McBride, M Ducatez, J Guy, P Brown, N Eterradossi, A Groene, JC Paulson, MH Verheijea

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2015

Abstract

ABSTRACTViruses exploit molecules on the target membrane as receptors for attachment and entry into host cells. Thus, receptor expression patterns can define viral tissue tropism and might to some extent predict the susceptibility of a host to a particular virus. Previously, others and we have shown that respiratory pathogens of the genusGammacoronavirus, including chicken infectious bronchitis virus (IBV), require specific α2,3-linked sialylated glycans for attachment and entry. Here, we studied determinants of binding of enterotropic avian gammacoronaviruses, including turkey coronavirus (TCoV), guineafowl coronavirus (GfCoV), and quail coronavirus (QCoV), which are evolutionarily distant ..

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Grants

Awarded by National Institutes of Health


Awarded by NIGMS


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

R.P.D.V. and M.H.V. are financially supported by NWO Rubicon and VENI and by NWO MEERVOUD, respectively. This work was funded in part by National Institutes of Health grant AI099274 to J.C.P. Several glycans used for binding assays were provided by the Consortium for Functional Glycomics (http://www.functionalglycomics.org/), funded by NIGMS grant GM62116 to J.C.P.