Journal article
Novel Receptor Specificity of Avian Gammacoronaviruses That Cause Enteritis
IN Ambepitiya Wickramasinghe, RP de Vries, EAWS Weerts, SJ van Beurden, W Peng, R McBride, M Ducatez, J Guy, P Brown, N Eterradossi, A Groene, JC Paulson, MH Verheijea
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2015
DOI: 10.1128/JVI.00745-15
Abstract
ABSTRACTViruses exploit molecules on the target membrane as receptors for attachment and entry into host cells. Thus, receptor expression patterns can define viral tissue tropism and might to some extent predict the susceptibility of a host to a particular virus. Previously, others and we have shown that respiratory pathogens of the genusGammacoronavirus, including chicken infectious bronchitis virus (IBV), require specific α2,3-linked sialylated glycans for attachment and entry. Here, we studied determinants of binding of enterotropic avian gammacoronaviruses, including turkey coronavirus (TCoV), guineafowl coronavirus (GfCoV), and quail coronavirus (QCoV), which are evolutionarily distant ..
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Awarded by National Institutes of Health
Awarded by NIGMS
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
Funding Acknowledgements
R.P.D.V. and M.H.V. are financially supported by NWO Rubicon and VENI and by NWO MEERVOUD, respectively. This work was funded in part by National Institutes of Health grant AI099274 to J.C.P. Several glycans used for binding assays were provided by the Consortium for Functional Glycomics (http://www.functionalglycomics.org/), funded by NIGMS grant GM62116 to J.C.P.