UNDERSTANDING THE RELATIONSHIP BETWEEN COGNITIVE HETEROGENEITY AND BRAIN MORPHOLOGY IN SCHIZOPHRENIA AND BIPOLAR DISORDER

Abstract

Although cognitive impairment is a recognized feature of schizophrenia (SZ) and bipolar disorder (BD), there is increasing evidence to suggest substantial patient-to-patient variation in cognitive ability that may reflect differences in underlying neurobiology. An expanding body of work has focused on probing this hypothesis by examining brain morphological patterns within subgroups of patients with SZ or BD classified using cognitive clustering approaches. This review aimed to summarise this work, with a view to providing insight into the extent to which brain morphological differences map on to cognitive subgroups within these disorders. Science Direct, PubMed, NCBI, and Web of Science dat..