Journal article

SAFETY AND EFFICACY OF RECOVERY-PROMOTING DRUGS FOR MOTOR FUNCTION AFTER STROKE: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS

Nerida Firth, Ruth N Barker, Kathryn S Hayward, Julie Bernhardt, Michelle Bellingan, Ronny Gunnarsson

JOURNAL OF REHABILITATION MEDICINE | FOUNDATION REHABILITATION INFORMATION | Published : 2019

Abstract

OBJECTIVE: To investigate the efficacy and safety of drug interventions to promote motor recovery post-stroke. DATA SOURCES: CENTRAL, CINAHL, Embase, MEDLINE, SCOPUS and Web of Science. STUDY SELECTION: Published human randomized controlled trials in which the primary intervention was a drug administered to promote motor recovery post-stroke, vs placebo. DATA EXTRACTION: Standardized pro forma used to extract safety and efficacy data; Cochrane Collaboration risk of bias assessment tool performed to assess risk of bias. DATA SYNTHESIS: Fifty randomized controlled trials from 4,779 citations were included. An overall trend of high risk of attrition (n = 27) and reporting bias (n = 36) was obse..

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Grants

Awarded by National Health and Medical Research Council Early Career Fellowship


Funding Acknowledgements

KSH is supported by a National Health and Medical Research Council Early Career Fellowship (GNT1088449).The Florey Institute of Neuroscience and Mental Health acknowledges support from the Victorian Government and funding from the Operational Infrastructure Support Grant.