Journal article

Pattern of neural activation following yohimbine-induced reinstatement of alcohol seeking in rats

Leigh C Walker, Hanna E Kastman, Andrew J Lawrence

EUROPEAN JOURNAL OF NEUROSCIENCE | WILEY | Published : 2020

Abstract

Alcohol use disorders represent an extensive socioeconomic burden, yet effective treatment options are suboptimal. A major hurdle in treating alcohol use disorders is the high rate of relapse. Stress is a major factor that promotes relapse in abstinent drug users; therefore, understanding neural mechanisms that underpin the effects of stress on alcohol seeking is critical. In rodent models of stress-induced relapse, the α2 -adrenoceptor antagonist, yohimbine, is a widely used chemical stressor to elicit reinstatement of drug/alcohol seeking. However, the exact mechanism how yohimbine precipitates reinstatement of alcohol seeking and the pattern of neural activation associated with yohimbine-..

View full abstract