GENE EXPRESSION SUGGEST ALTERED GLUTAMATERGIC, DOPAMINERGIC AND ESTROGEN CLASSICAL PATHWAYS IN WORKING MEMORY DEFICIT IN SCHIZOPHRENIA

Abstract

Schizophrenia has been associated with deficits across numerous cognitive domains. As cognitive impairments are poorly treated by antipsychotics, it is imperative to understand the molecular mechanisms influencing these deficits. While candidate gene studies have extensively explored cognitive performance in schizophrenia, there is a lack of studies investigating gene expression. As schizophrenia is a complex clinical disease, using gene expression profiling gives detailed insight to potential pathways involved in cognitive impairment. Research has shown that cognitive deficits should be investigated by separate domains rather than global cognition. As one of the most replicated deficits in ..